Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2264577..2265103 Replicon chromosome
Accession NZ_LR134216
Organism Escherichia coli strain NCTC10973

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL103_RS11010 Protein ID WP_000323025.1
Coordinates 2264816..2265103 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL103_RS11005 Protein ID WP_000534858.1
Coordinates 2264577..2264816 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL103_RS10970 2259691..2259942 + 252 Protein_2124 DUF977 family protein -
EL103_RS10975 2259939..2260295 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL103_RS22700 2260906..2261193 + 288 Protein_2126 hypothetical protein -
EL103_RS10990 2261962..2263275 + 1314 WP_000589005.1 ISNCY family transposase -
EL103_RS10995 2263712..2264044 - 333 WP_001301033.1 protein FlxA -
EL103_RS11000 2264247..2264552 - 306 WP_001326990.1 hypothetical protein -
EL103_RS11005 2264577..2264816 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL103_RS11010 2264816..2265103 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL103_RS11015 2265175..2265330 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL103_RS11020 2265547..2265798 + 252 WP_000980994.1 hypothetical protein -
EL103_RS11025 2265865..2266143 + 279 WP_012304870.1 hypothetical protein -
EL103_RS11030 2266145..2267194 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL103_RS11035 2267208..2267960 + 753 WP_001047135.1 antitermination protein -
EL103_RS11040 2268238..2268327 - 90 WP_120795389.1 hypothetical protein -
EL103_RS11045 2268382..2268594 - 213 WP_000087756.1 cold shock-like protein CspF -
EL103_RS11050 2268895..2269110 + 216 WP_000066484.1 cold shock-like protein CspB -
EL103_RS22795 2269474..2269644 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL103_RS11055 2269864..2270079 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2252044..2281016 28972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287096 WP_000323025.1 NZ_LR134216:2264816-2265103 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287096 WP_000534858.1 NZ_LR134216:2264577-2264816 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References