Detailed information of TA system TA286978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1560089..1560668
• Replicon: chromosome
• Accession: NZ_LR134193
• Organism: Staphylococcus aureus strain NCTC13616

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: EL036_RS07675
• Protein ID: WP_001025401.1
• Coordinates: 1560423..1560668 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1560089..1560454 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL036_RS07635	1556835..1557389	-	555	WP_000647288.1	DUF2815 family protein	-
EL036_RS07640	1557415..1558581	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
EL036_RS07645	1558578..1558940	-	363	WP_000985986.1	hypothetical protein	-
EL036_RS07650	1558955..1559278	-	324	WP_000175000.1	hypothetical protein	-
EL036_RS07655	1559357..1559518	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
EL036_RS07660	1559531..1559794	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
EL036_RS07665	1559819..1560034	-	216	WP_001097552.1	hypothetical protein	-
EL036_RS07670	1560089..1560454	+	366	WP_001128433.1	hypothetical protein	Antitoxin
EL036_RS07675	1560423..1560668	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
EL036_RS07680	1560735..1561115	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
EL036_RS07685	1561102..1561299	-	198	WP_001148860.1	hypothetical protein	-
EL036_RS07690	1561369..1561581	+	213	WP_000362644.1	hypothetical protein	-
EL036_RS14600	1561622..1561771	-	150	WP_000771849.1	hypothetical protein	-
EL036_RS07695	1561786..1562229	-	444	WP_000435357.1	hypothetical protein	-
EL036_RS07700	1562277..1562489	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
EL036_RS07705	1562641..1563372	+	732	WP_000511090.1	XRE family transcriptional regulator	-
EL036_RS07710	1563443..1563625	+	183	WP_000705240.1	hypothetical protein	-
EL036_RS07715	1563662..1563808	+	147	WP_001795334.1	hypothetical protein	-
EL036_RS07720	1563805..1564419	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1515948..1580722	64774

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T286978 WP_001025401.1 NZ_LR134193:c1560668-1560423 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT286978 NZ_LR134193:1560089-1560454 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin