Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2276984..2277510 Replicon chromosome
Accession NZ_LR134152
Organism Escherichia coli strain NCTC9104

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL040_RS11095 Protein ID WP_000323025.1
Coordinates 2277223..2277510 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL040_RS11090 Protein ID WP_000534858.1
Coordinates 2276984..2277223 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL040_RS11055 2272098..2272349 + 252 Protein_2145 DUF977 family protein -
EL040_RS11060 2272346..2272702 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL040_RS22950 2273313..2273600 + 288 Protein_2147 hypothetical protein -
EL040_RS11075 2274369..2275682 + 1314 WP_000589005.1 ISNCY family transposase -
EL040_RS11080 2276119..2276451 - 333 WP_001301033.1 protein FlxA -
EL040_RS11085 2276654..2276959 - 306 WP_001326990.1 hypothetical protein -
EL040_RS11090 2276984..2277223 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL040_RS11095 2277223..2277510 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL040_RS11100 2277582..2277737 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL040_RS11105 2277954..2278205 + 252 WP_000980994.1 hypothetical protein -
EL040_RS11110 2278272..2278550 + 279 WP_012304870.1 hypothetical protein -
EL040_RS11115 2278552..2279601 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL040_RS11120 2279615..2280367 + 753 WP_001047135.1 antitermination protein -
EL040_RS11125 2280645..2280734 - 90 WP_120795389.1 hypothetical protein -
EL040_RS11130 2280789..2281001 - 213 WP_000087756.1 cold shock-like protein CspF -
EL040_RS11135 2281302..2281517 + 216 WP_000066484.1 cold shock-like protein CspB -
EL040_RS23065 2281881..2282051 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL040_RS11140 2282271..2282486 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2256734..2298373 41639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T286886 WP_000323025.1 NZ_LR134152:2277223-2277510 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT286886 WP_000534858.1 NZ_LR134152:2276984-2277223 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References