Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4221081..4221745 Replicon chromosome
Accession NZ_LR134151
Organism Serratia plymuthica strain NCTC8900

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL066_RS20140 Protein ID WP_126484896.1
Coordinates 4221081..4221437 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2X4V2M0
Locus tag EL066_RS20145 Protein ID WP_063200237.1
Coordinates 4221443..4221745 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL066_RS20125 4218309..4219328 + 1020 WP_004952299.1 HTH-type transcriptional regulator GalR -
EL066_RS20130 4219325..4219781 - 457 Protein_3888 GNAT family N-acetyltransferase -
EL066_RS20135 4219933..4220942 + 1010 Protein_3889 LacI family DNA-binding transcriptional regulator -
EL066_RS20140 4221081..4221437 + 357 WP_126484896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL066_RS20145 4221443..4221745 + 303 WP_063200237.1 helix-turn-helix transcriptional regulator Antitoxin
EL066_RS20150 4221775..4223037 - 1263 WP_126484898.1 diaminopimelate decarboxylase -
EL066_RS20155 4223174..4224097 + 924 WP_126484900.1 LysR family transcriptional regulator -
EL066_RS20160 4224087..4225241 - 1155 WP_126484902.1 MFS transporter -
EL066_RS20165 4225557..4226465 - 909 WP_126484904.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13805.86 Da        Isoelectric Point: 9.7192

>T286874 WP_126484896.1 NZ_LR134151:4221081-4221437 [Serratia plymuthica]
MWQVITVERFDDWFLSLNDDEQKSLLAGIFKLQEFGPLLARPHADTLHFSGSIRHLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKTGDKRFYQRLLPIAAMEFSHYLATQR

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11126.05 Da        Isoelectric Point: 10.1425

>AT286874 WP_063200237.1 NZ_LR134151:4221443-4221745 [Serratia plymuthica]
MAKPLSNLIDKLDPTVVAAARQKAEKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVELPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4V2M0

References