Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3067225..3067850 Replicon chromosome
Accession NZ_LR134151
Organism Serratia plymuthica strain NCTC8900

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL066_RS14720 Protein ID WP_006321377.1
Coordinates 3067225..3067407 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL066_RS14725 Protein ID WP_126483414.1
Coordinates 3067437..3067850 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL066_RS14715 3063087..3067058 + 3972 WP_126483413.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
EL066_RS14720 3067225..3067407 + 183 WP_006321377.1 type II toxin-antitoxin system HicA family toxin Toxin
EL066_RS14725 3067437..3067850 + 414 WP_126483414.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL066_RS14730 3067885..3068637 - 753 WP_062871168.1 L-cystine ABC transporter ATP-binding protein YecC -
EL066_RS14735 3068641..3069302 - 662 Protein_2848 cystine ABC transporter permease -
EL066_RS14740 3069302..3070102 - 801 WP_126483416.1 cystine ABC transporter substrate-binding protein -
EL066_RS14745 3070217..3071209 - 993 WP_126483418.1 D-cysteine desulfhydrase -
EL066_RS14750 3071336..3071845 - 510 WP_126483420.1 flagella biosynthesis regulatory protein FliZ -
EL066_RS14755 3071902..3072624 - 723 WP_126483422.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7004.29 Da        Isoelectric Point: 11.5336

>T286868 WP_006321377.1 NZ_LR134151:3067225-3067407 [Serratia plymuthica]
VKSAELIRLLEREGWVLERIKGSHHQFKHPRSRLVITVPHPRKDLKPGTLRQIMRDAGLC

Download         Length: 183 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15018.73 Da        Isoelectric Point: 4.8469

>AT286868 WP_126483414.1 NZ_LR134151:3067437-3067850 [Serratia plymuthica]
MFYPAYVHSDHDGSASGFFPDVPGCYFAGDTLDIAFEDAKSALDAHFELLSEDNQAIPRPQAVSFHLAQASDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References