Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1115904..1116526 Replicon chromosome
Accession NZ_LR134151
Organism Serratia plymuthica strain NCTC8900

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag EL066_RS05390 Protein ID WP_006322256.1
Coordinates 1115904..1116107 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag EL066_RS05395 Protein ID WP_004949348.1
Coordinates 1116158..1116526 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL066_RS05375 1111710..1113080 + 1371 WP_126480739.1 amidase -
EL066_RS05380 1113128..1115068 - 1941 WP_126480741.1 NAD(P)/FAD-dependent oxidoreductase -
EL066_RS05385 1115450..1115677 + 228 WP_126480743.1 hypothetical protein -
EL066_RS05390 1115904..1116107 - 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
EL066_RS05395 1116158..1116526 - 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
EL066_RS05400 1116687..1117013 - 327 WP_126480745.1 hypothetical protein -
EL066_RS05410 1117492..1118205 + 714 WP_126480749.1 ABC transporter ATP-binding protein -
EL066_RS05415 1118202..1119059 + 858 WP_073439483.1 metal ABC transporter permease -
EL066_RS05420 1119085..1119963 + 879 WP_126480751.1 metal ABC transporter substrate-binding protein -
EL066_RS05425 1120079..1120219 - 141 WP_013811779.1 type B 50S ribosomal protein L36 -
EL066_RS05430 1120232..1120486 - 255 WP_126480753.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T286861 WP_006322256.1 NZ_LR134151:c1116107-1115904 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT286861 WP_004949348.1 NZ_LR134151:c1116526-1116158 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References