Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yfjZ/CbtA-CbeA |
| Location | 267183..267965 | Replicon | chromosome |
| Accession | NZ_LR134117 | ||
| Organism | Serratia odorifera strain NCTC11214 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | D4DW19 |
| Locus tag | EL065_RS01460 | Protein ID | WP_004954396.1 |
| Coordinates | 267183..267518 (+) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | D4DW20 |
| Locus tag | EL065_RS01465 | Protein ID | WP_004954398.1 |
| Coordinates | 267594..267965 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EL065_RS01420 | 262680..263885 | + | 1206 | WP_039992976.1 | IS256 family transposase | - |
| EL065_RS01435 | 264653..265120 | + | 468 | WP_182646422.1 | hypothetical protein | - |
| EL065_RS01440 | 265356..265802 | + | 447 | WP_039991024.1 | antirestriction protein | - |
| EL065_RS01445 | 265822..266301 | + | 480 | WP_004954391.1 | DNA repair protein RadC | - |
| EL065_RS01450 | 266312..266632 | + | 321 | WP_050763089.1 | hypothetical protein | - |
| EL065_RS01455 | 266709..267170 | + | 462 | WP_102991113.1 | hypothetical protein | - |
| EL065_RS01460 | 267183..267518 | + | 336 | WP_004954396.1 | TA system toxin CbtA family protein | Toxin |
| EL065_RS01465 | 267594..267965 | + | 372 | WP_004954398.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| EL065_RS01470 | 268045..268902 | + | 858 | WP_004954401.1 | DUF4942 domain-containing protein | - |
| EL065_RS01480 | 269401..270267 | + | 867 | WP_004954407.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | - |
| EL065_RS01485 | 270278..270490 | + | 213 | WP_004954409.1 | ribosome-associated protein YbcJ | - |
| EL065_RS01490 | 270545..271930 | - | 1386 | WP_004954412.1 | cysteine--tRNA ligase | - |
| EL065_RS01495 | 272210..272704 | + | 495 | WP_004954414.1 | peptidylprolyl isomerase B | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 262680..263885 | 1205 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12625.49 Da Isoelectric Point: 7.2774
>T286821 WP_004954396.1 NZ_LR134117:267183-267518 [Serratia odorifera]
MKTLDKIPRITPSANQARTEYQQLLAWLLAHCYGLELNDTPYHDEQAIAKQIEHGITVRETVNELVEKFDLVRIDRPGFS
LMAQDPLLNGGDMLRARSALGLRSPVNRRLT
MKTLDKIPRITPSANQARTEYQQLLAWLLAHCYGLELNDTPYHDEQAIAKQIEHGITVRETVNELVEKFDLVRIDRPGFS
LMAQDPLLNGGDMLRARSALGLRSPVNRRLT
Download Length: 336 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13631.27 Da Isoelectric Point: 5.8701
>AT286821 WP_004954398.1 NZ_LR134117:267594-267965 [Serratia odorifera]
MKDTDNQTNLNTHNDITPIWGLQSAITPRLGARLVQQGNHLHFLADRAGLVGTFDSDALQMLDTAFPVLIEQLEVRLRSG
ELDQRRQHCVTVQHAGFTCEADTLGSFGHVYIAVYQTTPSNTV
MKDTDNQTNLNTHNDITPIWGLQSAITPRLGARLVQQGNHLHFLADRAGLVGTFDSDALQMLDTAFPVLIEQLEVRLRSG
ELDQRRQHCVTVQHAGFTCEADTLGSFGHVYIAVYQTTPSNTV
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S4DSQ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A447KKW1 |