Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2568598..2570186 Replicon chromosome
Accession NZ_LR133964
Organism Klebsiella pneumoniae strain NCTC11359

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag EL047_RS12845 Protein ID WP_004176197.1
Coordinates 2568598..2569920 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag EL047_RS12850 Protein ID WP_002904790.1
Coordinates 2569920..2570186 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL047_RS12825 2563663..2566155 + 2493 WP_126438606.1 fimbrial biogenesis outer membrane usher protein -
EL047_RS12830 2566143..2567147 + 1005 WP_040241874.1 type 1 fimbrial protein -
EL047_RS12840 2567289..2568581 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
EL047_RS12845 2568598..2569920 - 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
EL047_RS12850 2569920..2570186 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EL047_RS12855 2570451..2570777 - 327 WP_002904788.1 hydroxyisourate hydrolase -
EL047_RS12860 2570774..2571274 - 501 WP_023285113.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EL047_RS12865 2571252..2572631 - 1380 WP_004184021.1 purine permease -
EL047_RS12870 2572977..2574131 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
EL047_RS12875 2574112..2575035 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T286534 WP_004176197.1 NZ_LR133964:c2569920-2568598 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT286534 WP_002904790.1 NZ_LR133964:c2570186-2569920 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References