Detailed information of TA system TA028650

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 691510..691950
• Replicon: chromosome
• Accession: NC_019902
• Organism: Thioalkalivibrio nitratireducens DSM 14787

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: TVNIR_RS03565
• Protein ID: WP_211263175.1
• Coordinates: 691765..691950 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: L0DS88
• Locus tag: TVNIR_RS03560
• Protein ID: WP_015257607.1
• Coordinates: 691510..691719 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TVNIR_RS03515	686912..687157	+	246	WP_043739237.1	hypothetical protein	-
TVNIR_RS03520	687424..687855	-	432	WP_015257600.1	PIN domain-containing protein	-
TVNIR_RS03525	687842..688072	-	231	WP_015257601.1	ribbon-helix-helix protein, CopG family	-
TVNIR_RS03530	688286..688621	+	336	WP_043740123.1	DUF1778 domain-containing protein	-
TVNIR_RS03535	688566..689081	+	516	WP_043739239.1	GNAT family N-acetyltransferase	-
TVNIR_RS03540	689127..689342	+	216	WP_015257604.1	hypothetical protein	-
TVNIR_RS03545	689597..690370	+	774	WP_015257605.1	YdcF family protein	-
TVNIR_RS03550	690461..690901	-	441	WP_015257606.1	putative toxin-antitoxin system toxin component, PIN family	-
TVNIR_RS03555	690883..691104	-	222	WP_006749192.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
TVNIR_RS03560	691510..691719	+	210	WP_015257607.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
TVNIR_RS03565	691765..691950	+	186	WP_211263175.1	type II toxin-antitoxin system HicA family toxin	Toxin
TVNIR_RS03570	692204..693097	+	894	WP_015257610.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
TVNIR_RS03575	693624..693911	+	288	WP_006749202.1	GIY-YIG nuclease family protein	-
TVNIR_RS03580	694208..694642	-	435	WP_015257611.1	PIN domain-containing protein	-
TVNIR_RS03585	694642..694887	-	246	WP_043739242.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-51)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-51)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6946.99 Da
• Isoelectric Point: 11.8066

>T28650 WP_211263175.1 NC_019902:691765-691950 [Thioalkalivibrio nitratireducens DSM 14787]
ILLRLGFVEVRQRGSHKHFRHPDGRATTVPFHAGRHISTPLLRQIIKDIGLTPDDFLTNHG

Nucleotide

• Length: 186 bp

>T28650 NC_019902:691765-691950 [Thioalkalivibrio nitratireducens DSM 14787]
ATCCTTTTGCGACTCGGTTTCGTCGAGGTTCGCCAAAGAGGTTCGCATAAGCACTTCAGGCATCCGGATGGAAGAGCGAC
AACGGTGCCATTCCACGCCGGCCGGCACATCTCCACACCGTTGCTGCGGCAGATCATCAAGGATATCGGGCTCACCCCCG
ACGATTTTCTGACCAACCATGGATGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7644.58 Da
• Isoelectric Point: 3.8770

>AT28650 WP_015257607.1 NC_019902:691510-691719 [Thioalkalivibrio nitratireducens DSM 14787]
MRQYSAVVERCPQTGYYVGFIPGFPGAHSQAETLDELQSNLKEVIEMLLEDGEPQLESEFVGVQQIAVA

Nucleotide

• Length: 210 bp

>AT28650 NC_019902:691510-691719 [Thioalkalivibrio nitratireducens DSM 14787]
ATGAGACAGTACTCTGCAGTCGTCGAACGCTGCCCGCAGACCGGGTATTACGTGGGCTTCATTCCCGGATTCCCTGGTGC
GCACAGTCAGGCGGAAACGTTGGACGAGTTACAAAGCAACCTTAAGGAAGTCATCGAGATGCTGCTGGAGGACGGCGAGC
CGCAGTTGGAATCCGAGTTCGTCGGAGTTCAACAGATCGCAGTTGCCTGA

Structures

Antitoxin

• AlphaFold DB: L0DS88