Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 634787..635586 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag EW037_RS03080 Protein ID WP_000347270.1
Coordinates 634787..635251 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0V9H1L4
Locus tag EW037_RS03085 Protein ID WP_001551693.1
Coordinates 635251..635586 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS03050 629788..630222 - 435 WP_000948837.1 PTS sugar transporter subunit IIA -
EW037_RS03055 630240..631118 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EW037_RS03060 631108..631887 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EW037_RS03065 631898..632371 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EW037_RS03070 632394..633674 - 1281 WP_001551694.1 tagatose-bisphosphate aldolase subunit KbaZ -
EW037_RS03075 633923..634732 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
EW037_RS03080 634787..635251 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EW037_RS03085 635251..635586 - 336 WP_001551693.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EW037_RS03090 635735..637306 - 1572 WP_001273738.1 galactarate dehydratase -
EW037_RS03095 637681..639015 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
EW037_RS03100 639031..639801 + 771 WP_001551692.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T286451 WP_000347270.1 NZ_LR130562:c635251-634787 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12347.87 Da        Isoelectric Point: 4.6890

>AT286451 WP_001551693.1 NZ_LR130562:c635586-635251 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9H1L4

References