Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3338784..3339489 Replicon chromosome
Accession NZ_LR130555
Organism Escherichia coli strain MS14385 isolate MS14385

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag EW040_RS16330 Protein ID WP_000539521.1
Coordinates 3338784..3339170 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EW040_RS16335 Protein ID WP_001280945.1
Coordinates 3339160..3339489 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW040_RS16310 3334788..3335414 + 627 WP_001295292.1 glutathione S-transferase GstB -
EW040_RS16315 3335411..3336526 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
EW040_RS16320 3336637..3337020 - 384 WP_000497137.1 biofilm formation regulator BssR -
EW040_RS16325 3337233..3338558 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
EW040_RS16330 3338784..3339170 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW040_RS16335 3339160..3339489 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
EW040_RS16340 3339559..3340887 - 1329 WP_022645414.1 GGDEF domain-containing protein -
EW040_RS16345 3340895..3343243 - 2349 WP_022645413.1 EAL domain-containing protein -
EW040_RS16350 3343420..3344331 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T286429 WP_000539521.1 NZ_LR130555:3338784-3339170 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT286429 WP_001280945.1 NZ_LR130555:3339160-3339489 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References