Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4416096..4416931 Replicon chromosome
Accession NZ_LR130545
Organism Escherichia coli strain B36 isolate B36

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag EW036_RS22170 Protein ID WP_000854759.1
Coordinates 4416096..4416473 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag EW036_RS22175 Protein ID WP_001295723.1
Coordinates 4416563..4416931 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW036_RS22145 4412207..4413847 - 1641 WP_001332039.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -
EW036_RS22150 4414620..4414796 - 177 Protein_4248 helix-turn-helix domain-containing protein -
EW036_RS26755 4415160..4415318 - 159 WP_001467148.1 hypothetical protein -
EW036_RS22160 4415418..4415594 - 177 WP_000839286.1 DUF957 domain-containing protein -
EW036_RS22165 4415611..4416099 - 489 WP_000761690.1 hypothetical protein -
EW036_RS22170 4416096..4416473 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
EW036_RS22175 4416563..4416931 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EW036_RS22180 4417204..4417950 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
EW036_RS22185 4417965..4419506 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
EW036_RS22190 4419647..4419901 - 255 WP_023281719.1 DUF987 domain-containing protein -
EW036_RS22195 4419964..4420440 - 477 WP_001186775.1 RadC family protein -
EW036_RS22200 4420456..4420929 - 474 WP_001350782.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T286370 WP_000854759.1 NZ_LR130545:c4416473-4416096 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT286370 WP_001295723.1 NZ_LR130545:c4416931-4416563 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References