Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4864086..4864602 Replicon chromosome
Accession NZ_LR130544
Organism Klebsiella variicola strain 03-311-0071 isolate 03-311-0071

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag EW041_RS23710 Protein ID WP_002886902.1
Coordinates 4864086..4864370 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EW041_RS23715 Protein ID WP_047667304.1
Coordinates 4864360..4864602 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW041_RS23695 4859189..4860844 + 1656 WP_129766172.1 alpha,alpha-phosphotrehalase -
EW041_RS23700 4861230..4863368 + 2139 WP_044614392.1 anaerobic ribonucleoside-triphosphate reductase -
EW041_RS23705 4863618..4864082 + 465 WP_012969085.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EW041_RS23710 4864086..4864370 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW041_RS23715 4864360..4864602 - 243 WP_047667304.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EW041_RS23720 4864680..4866590 - 1911 WP_129766173.1 BglG family transcription antiterminator -
EW041_RS23725 4866613..4867767 - 1155 WP_012543086.1 lactonase family protein -
EW041_RS23730 4867893..4868633 - 741 WP_008807137.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T286345 WP_002886902.1 NZ_LR130544:c4864370-4864086 [Klebsiella variicola]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9103.58 Da        Isoelectric Point: 5.1351

>AT286345 WP_047667304.1 NZ_LR130544:c4864602-4864360 [Klebsiella variicola]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDDEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure

References