Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3964206..3964803 Replicon chromosome
Accession NZ_LR130538
Organism Klebsiella variicola strain AJ292 isolate AJ292

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag EW044_RS19595 Protein ID WP_012542526.1
Coordinates 3964486..3964803 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EW044_RS19590 Protein ID WP_012542525.1
Coordinates 3964206..3964493 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW044_RS19560 3960116..3960364 + 249 WP_008805539.1 DUF1158 domain-containing protein -
EW044_RS19565 3960381..3960722 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
EW044_RS19570 3960753..3961868 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
EW044_RS19575 3962048..3962629 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
EW044_RS19580 3962629..3962997 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
EW044_RS19585 3963117..3963770 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
EW044_RS19590 3964206..3964493 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
EW044_RS19595 3964486..3964803 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW044_RS19600 3964988..3966031 - 1044 WP_016160437.1 DUF2157 domain-containing protein -
EW044_RS19610 3966561..3967427 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
EW044_RS19615 3967536..3968963 + 1428 WP_023297179.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T286282 WP_012542526.1 NZ_LR130538:c3964803-3964486 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT286282 WP_012542525.1 NZ_LR130538:c3964493-3964206 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References