Detailed information of TA system TA286111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 952487..953724
• Replicon: chromosome
• Accession: NZ_LR129843
• Organism: Streptococcus pneumoniae strain 180-2 isolate 180-2

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A4J1ZCF4
• Locus tag: EQB46_RS05195
• Protein ID: WP_000405368.1
• Coordinates: 952963..953724 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: EQB46_RS05190
• Protein ID: WP_000579602.1
• Coordinates: 952487..952963 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQB46_RS05170	947560..948414	+	855	WP_000900019.1	ADP-ribosylglycohydrolase family protein	-
EQB46_RS05175	948526..949410	+	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
EQB46_RS05180	949573..951312	+	1740	WP_000423464.1	glycoside hydrolase family 13 protein	-
EQB46_RS05185	951587..952042	+	456	WP_000500478.1	hypothetical protein	-
EQB46_RS05190	952487..952963	+	477	WP_000579602.1	helix-turn-helix domain-containing protein	Antitoxin
EQB46_RS05195	952963..953724	+	762	WP_000405368.1	zeta toxin family protein	Toxin
EQB46_RS05200	953752..954909	+	1158	WP_001213951.1	hypothetical protein	-
EQB46_RS05215	955741..956100	+	360	WP_000529545.1	hypothetical protein	-
EQB46_RS05220	956110..956475	+	366	WP_000263039.1	MobC family plasmid mobilization relaxosome protein	-
EQB46_RS11500	956462..958312	+	1851	Protein_982	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	937231..982704	45473

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29185.27 Da
• Isoelectric Point: 7.5090

>T286111 WP_000405368.1 NZ_LR129843:952963-953724 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFVGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
RVGEKRLNELLEK

Nucleotide

• Length: 762 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18289.70 Da
• Isoelectric Point: 4.4188

>AT286111 WP_000579602.1 NZ_LR129843:952487-952963 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A4J1ZCF4