Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1790312..1790792 Replicon chromosome
Accession NC_019776
Organism Cyanobacterium aponinum PCC 10605

Toxin (Protein)


Gene name - Uniprot ID K9Z5C8
Locus tag CYAN10605_RS07490 Protein ID WP_015219337.1
Coordinates 1790532..1790792 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID K9Z4E0
Locus tag CYAN10605_RS07485 Protein ID WP_015219336.1
Coordinates 1790312..1790542 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYAN10605_RS07455 1785386..1785883 + 498 WP_015219330.1 hypothetical protein -
CYAN10605_RS07460 1785918..1786457 + 540 WP_015219331.1 DUF2808 domain-containing protein -
CYAN10605_RS07465 1786516..1786959 + 444 WP_015219332.1 hypothetical protein -
CYAN10605_RS07470 1787827..1789449 + 1623 WP_015219333.1 hypothetical protein -
CYAN10605_RS07475 1789560..1790051 + 492 WP_015219334.1 dual specificity protein phosphatase family protein -
CYAN10605_RS07480 1790068..1790292 - 225 WP_015219335.1 type II toxin-antitoxin system HicB family antitoxin -
CYAN10605_RS07485 1790312..1790542 - 231 WP_015219336.1 hypothetical protein Antitoxin
CYAN10605_RS07490 1790532..1790792 - 261 WP_015219337.1 BrnT family toxin Toxin
CYAN10605_RS07495 1790888..1793533 + 2646 WP_015219338.1 alanine--tRNA ligase -
CYAN10605_RS18140 1793947..1794096 + 150 WP_071880491.1 DNA-binding protein -
CYAN10605_RS07505 1794285..1794578 - 294 WP_015219339.1 hypothetical protein -
CYAN10605_RS07510 1794622..1795050 - 429 WP_015217945.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin

CopG antitoxin

(14-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10502.96 Da        Isoelectric Point: 9.3991

>T28603 WP_015219337.1 NC_019776:c1790792-1790532 [Cyanobacterium aponinum PCC 10605]
MEFEYDENKSNINKEKHGIDFEEAQLLWLDNNRIEIKANSTNEFRMIIIGKIKEKYWSAIITYRQTKIRIISVRRSRKQE
VNFYES

Download         Length: 261 bp

>T28603 NC_019776:c1790792-1790532 [Cyanobacterium aponinum PCC 10605]
ATGGAATTTGAGTATGATGAAAATAAAAGTAATATCAATAAAGAAAAACACGGCATTGATTTTGAAGAAGCCCAGTTATT
ATGGTTAGACAATAATCGGATTGAGATAAAAGCAAATTCAACCAATGAATTTCGGATGATAATAATTGGTAAAATTAAGG
AAAAATATTGGTCTGCAATAATAACATATCGCCAAACTAAAATTAGAATTATATCTGTTAGACGTTCGAGAAAACAAGAG
GTAAATTTTTATGAAAGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8784.22 Da        Isoelectric Point: 4.5098

>AT28603 WP_015219336.1 NC_019776:c1790542-1790312 [Cyanobacterium aponinum PCC 10605]
MKAEELDLLFEEGKEDILEYFDLSTAKRPALEKTKIDLDLPQWMIIALDKEAKRLGIESQSLIKVWIAQHLDSAKI

Download         Length: 231 bp

>AT28603 NC_019776:c1790542-1790312 [Cyanobacterium aponinum PCC 10605]
ATGAAAGCTGAAGAATTAGATTTATTATTTGAAGAAGGAAAAGAAGATATTTTAGAATATTTTGATTTATCAACGGCAAA
GCGCCCTGCTTTGGAAAAGACAAAAATTGATTTGGATTTACCCCAATGGATGATAATTGCCTTAGATAAAGAAGCAAAAA
GATTAGGTATTGAGTCTCAATCTTTAATTAAAGTTTGGATTGCTCAACATTTAGATTCCGCTAAAATATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A844GVX7

Antitoxin

Source ID Structure
AlphaFold DB K9Z4E0

References