Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4444921..4445516 Replicon chromosome
Accession NZ_LN832404
Organism Escherichia coli K-12 substr. AG100

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag EK12AG100_RS21980 Protein ID WP_000239577.1
Coordinates 4445166..4445516 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag EK12AG100_RS21975 Protein ID WP_001223208.1
Coordinates 4444921..4445172 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK12AG100_RS21965 4440586..4444365 + 3780 WP_046609143.1 autotransporter assembly complex protein TamB -
EK12AG100_RS21970 4444368..4444709 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
EK12AG100_RS21975 4444921..4445172 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
EK12AG100_RS21980 4445166..4445516 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
EK12AG100_RS21985 4445596..4446126 - 531 WP_000055075.1 inorganic diphosphatase -
EK12AG100_RS21990 4446436..4447392 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
EK12AG100_RS21995 4447532..4449034 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
EK12AG100_RS22000 4449048..4450070 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T285672 WP_000239577.1 NZ_LN832404:4445166-4445516 [Escherichia coli K-12]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT285672 WP_001223208.1 NZ_LN832404:4444921-4445172 [Escherichia coli K-12]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References