Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 1081585..1082192 Replicon chromosome
Accession NZ_LN681225
Organism Legionella hackeliae strain ATCC 35250

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A8USV8
Locus tag LHA_RS04950 Protein ID WP_045105551.1
Coordinates 1081585..1081839 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0A8UN44
Locus tag LHA_RS04955 Protein ID WP_045105552.1
Coordinates 1081836..1082192 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHA_RS16500 1077818..1079341 - 1524 Protein_953 diguanylate cyclase -
LHA_RS04940 1079716..1080735 + 1020 WP_045105549.1 site-specific integrase -
LHA_RS04945 1080843..1081463 + 621 WP_045105550.1 helix-turn-helix domain-containing protein -
LHA_RS04950 1081585..1081839 + 255 WP_045105551.1 type II toxin-antitoxin system HicA family toxin Toxin
LHA_RS04955 1081836..1082192 + 357 WP_045105552.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LHA_RS04960 1082209..1083057 + 849 WP_045105553.1 hypothetical protein -
LHA_RS04965 1083456..1083833 + 378 WP_045105554.1 hypothetical protein -
LHA_RS04970 1083830..1084558 + 729 WP_045105555.1 hypothetical protein -
LHA_RS04975 1084555..1085043 + 489 WP_045105556.1 hypothetical protein -
LHA_RS04985 1085877..1086368 + 492 WP_045105558.1 hypothetical protein -
LHA_RS04990 1086476..1086865 + 390 WP_045105559.1 type II toxin-antitoxin system RelE/ParE family toxin -
LHA_RS04995 1086858..1087160 + 303 WP_045105560.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(55-102)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9875.58 Da        Isoelectric Point: 10.4749

>T285543 WP_045105551.1 NZ_LN681225:1081585-1081839 [Legionella hackeliae]
MTKIDKLRQRFLSKPKDFTWDELRVLLKSMGFEEYNSGKTSGSRVKFIHTQYGDIMLHKPHPNPELKGYQIKQILAQLKK
EGLL

Download         Length: 255 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13643.59 Da        Isoelectric Point: 5.2973

>AT285543 WP_045105552.1 NZ_LN681225:1081836-1082192 [Legionella hackeliae]
MKNMLKHKGYYGSIEFDSEDLIFYGKLEFINSLISYEGETAKEIDKAFKEAVEDYLISCKDRGIEPEKPFKGSLNVRIGP
ERHEKATLMAKEMGCSSLNDFFKIALDHEFERYLKTVS

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8USV8

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8UN44

References