Detailed information of TA system TA028535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 2064756..2065384
• Replicon: chromosome
• Accession: NC_019729
• Organism: Oscillatoria nigro-viridis PCC 7112

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K9VDL6
• Locus tag: OSC7112_RS08810
• Protein ID: WP_015175580.1
• Coordinates: 2064983..2065384 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K9VFK5
• Locus tag: OSC7112_RS08805
• Protein ID: WP_015175579.1
• Coordinates: 2064756..2064986 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OSC7112_RS08795	2059955..2064415	+	4461	WP_015175577.1	NACHT domain-containing protein	-
OSC7112_RS08800	2064435..2064647	+	213	WP_015175578.1	hypothetical protein	-
OSC7112_RS08805	2064756..2064986	+	231	WP_015175579.1	virulence associated protein B	Antitoxin
OSC7112_RS08810	2064983..2065384	+	402	WP_015175580.1	type II toxin-antitoxin system VapC family toxin	Toxin
OSC7112_RS08820	2065622..2067349	-	1728	WP_015175581.1	ABC transporter ATP-binding protein/permease	-
OSC7112_RS08825	2067661..2068143	-	483	WP_015175582.1	FxLYD domain-containing protein	-
OSC7112_RS08830	2068288..2069043	+	756	WP_015175583.1	Uma2 family endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15024.43 Da
• Isoelectric Point: 5.1613

>T28535 WP_015175580.1 NC_019729:2064983-2065384 [Oscillatoria nigro-viridis PCC 7112]
MRFLLDTNICIYIIKQKPQKVFEKFQTVEIFDIGISSVTIAELEYGVYKSQRQEQNRAALTQFLITLPIVAFDERCTQTY
GQIRAGLERQGIVAGAMDLLIASQAISLGLTLVTNNVRELSRIPGLTLENWVD

Nucleotide

• Length: 402 bp

>T28535 NC_019729:2064983-2065384 [Oscillatoria nigro-viridis PCC 7112]
ATGAGATTTTTACTGGATACTAACATCTGCATCTACATCATCAAGCAAAAACCCCAAAAAGTTTTCGAGAAATTCCAAAC
AGTTGAAATTTTTGATATCGGTATTTCATCTGTTACTATTGCTGAACTTGAGTATGGCGTTTACAAGAGTCAGCGTCAAG
AGCAAAATCGGGCAGCACTTACTCAGTTTTTAATAACTTTACCAATAGTTGCTTTTGATGAAAGATGCACGCAAACTTAT
GGACAAATTAGAGCAGGATTAGAACGTCAAGGTATTGTCGCGGGTGCAATGGATTTGCTGATAGCTTCCCAAGCAATCAG
TTTGGGGCTGACACTGGTGACGAATAATGTGAGAGAATTGTCCCGTATCCCAGGATTAACCTTAGAAAATTGGGTTGATT
AG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8836.02 Da
• Isoelectric Point: 4.1541

>AT28535 WP_015175579.1 NC_019729:2064756-2064986 [Oscillatoria nigro-viridis PCC 7112]
MNTAKLSLADDYQTVILPKEFHFAGNEVYVKKIGDALVLISKENPWTTFFDSLNMFSDDFMLVREQLPVESREDFE

Nucleotide

• Length: 231 bp

>AT28535 NC_019729:2064756-2064986 [Oscillatoria nigro-viridis PCC 7112]
ATGAATACTGCTAAATTATCGCTAGCTGATGACTATCAGACAGTCATATTACCCAAAGAATTCCATTTTGCAGGAAATGA
AGTGTACGTCAAAAAAATAGGAGATGCTCTTGTCCTGATCTCGAAAGAAAATCCTTGGACAACTTTTTTTGATAGTTTGA
ATATGTTCTCGGACGACTTTATGCTAGTTAGGGAGCAGCTTCCTGTGGAGAGTAGAGAGGATTTTGAATGA

Structures

Toxin

• AlphaFold DB: K9VDL6

Antitoxin

• AlphaFold DB: K9VFK5