Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4974597..4975432 Replicon chromosome
Accession NZ_HG941718
Organism Escherichia coli O25b:H4-ST131 strain EC958

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag EC958_RS24870 Protein ID WP_000854759.1
Coordinates 4975055..4975432 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag EC958_RS24865 Protein ID WP_001295723.1
Coordinates 4974597..4974965 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC958_RS24835 4970599..4971072 + 474 WP_001350782.1 antirestriction protein -
EC958_RS24840 4971088..4971564 + 477 WP_001186775.1 RadC family protein -
EC958_RS24845 4971627..4971881 + 255 WP_023281719.1 DUF987 domain-containing protein -
EC958_RS24850 4972022..4973563 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
EC958_RS24855 4973578..4974324 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
EC958_RS24865 4974597..4974965 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EC958_RS24870 4975055..4975432 + 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
EC958_RS24875 4975429..4975917 + 489 WP_000761690.1 hypothetical protein -
EC958_RS24880 4975934..4976110 + 177 WP_000839286.1 DUF957 domain-containing protein -
EC958_RS29720 4976210..4976368 + 159 WP_001467148.1 hypothetical protein -
EC958_RS29445 4976732..4976908 + 177 Protein_4704 helix-turn-helix domain-containing protein -
EC958_RS24890 4977681..4979321 + 1641 WP_001332039.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T285210 WP_000854759.1 NZ_HG941718:4975055-4975432 [Escherichia coli O25b:H4-ST131]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT285210 WP_001295723.1 NZ_HG941718:4974597-4974965 [Escherichia coli O25b:H4-ST131]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References