Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4195421..4196256 Replicon chromosome
Accession NZ_HG941718
Organism Escherichia coli O25b:H4-ST131 strain EC958

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag EC958_RS21065 Protein ID WP_001094448.1
Coordinates 4195879..4196256 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag EC958_RS21060 Protein ID WP_024175935.1
Coordinates 4195421..4195789 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC958_RS21035 4192850..4193083 + 234 WP_001117568.1 DUF905 family protein -
EC958_RS21040 4193174..4193992 + 819 WP_001234753.1 DUF945 domain-containing protein -
EC958_RS21045 4194084..4194569 + 486 WP_000214415.1 antirestriction protein -
EC958_RS21050 4194581..4195057 + 477 WP_001186709.1 RadC family protein -
EC958_RS21055 4195126..4195347 + 222 WP_000692346.1 DUF987 domain-containing protein -
EC958_RS21060 4195421..4195789 + 369 WP_024175935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EC958_RS21065 4195879..4196256 + 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
EC958_RS21070 4196253..4196741 + 489 WP_000761714.1 hypothetical protein -
EC958_RS21075 4196753..4196974 + 222 WP_001296561.1 DUF957 domain-containing protein -
EC958_RS21080 4197030..4197875 + 846 WP_000065751.1 DUF4942 domain-containing protein -
EC958_RS21090 4198468..4198965 + 498 WP_000509815.1 hypothetical protein -
EC958_RS21095 4199143..4200066 + 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
EC958_RS21100 4200070..4200888 - 819 WP_000779409.1 lipoprotein NlpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4187890..4198965 11075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T285206 WP_001094448.1 NZ_HG941718:4195879-4196256 [Escherichia coli O25b:H4-ST131]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT285206 WP_024175935.1 NZ_HG941718:4195421-4195789 [Escherichia coli O25b:H4-ST131]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7EC32

References