Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1157406..1157628 Replicon chromosome
Accession NZ_HG738867
Organism Escherichia coli str. K-12 substr. MC4100 strain K-12

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag BN896_RS05765 Protein ID WP_000170955.1
Coordinates 1157406..1157513 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1157561..1157628 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN896_RS05735 (BN896_1037) 1153262..1154095 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
BN896_RS05740 (BN896_1038) 1154092..1154484 + 393 WP_000200374.1 invasion regulator SirB2 -
BN896_RS05745 (BN896_1039) 1154488..1155297 + 810 WP_001257044.1 invasion regulator SirB1 -
BN896_RS05750 (BN896_1040) 1155333..1156187 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
BN896_RS05755 (BN896_1041) 1156336..1156443 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
BN896_RS05760 (BN896_1042) 1156871..1156978 - 108 WP_000170963.1 small toxic polypeptide LdrB -
BN896_RS05765 (BN896_1043) 1157406..1157513 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC Toxin
- 1157561..1157628 + 68 - - Antitoxin
BN896_RS05770 (BN896_1044) 1157917..1159017 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
BN896_RS05775 (BN896_1045) 1159287..1159517 + 231 WP_001146444.1 putative cation transport regulator ChaB -
BN896_RS05780 (BN896_1046) 1159675..1160370 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
BN896_RS05785 (BN896_1047) 1160414..1160767 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
BN896_RS05790 (BN896_1048) 1160952..1162346 + 1395 WP_000086217.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T285009 WP_000170955.1 NZ_HG738867:c1157513-1157406 [Escherichia coli str. K-12 substr. MC4100]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T285009 NZ_HG738867:c1157513-1157406 [Escherichia coli str. K-12 substr. MC4100]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 68 bp

>AT285009 NZ_HG738867:1157561-1157628 [Escherichia coli str. K-12 substr. MC4100]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References