Detailed information of TA system TA028495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2865706..2866276
• Replicon: chromosome
• Accession: NC_019676
• Organism: Nostoc sp. PCC 7107

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K9QDA6
• Locus tag: NOS7107_RS12190
• Protein ID: WP_015113279.1
• Coordinates: 2865977..2866276 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K9QCG7
• Locus tag: NOS7107_RS12185
• Protein ID: WP_015113278.1
• Coordinates: 2865706..2865996 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOS7107_RS12165	2862204..2862540	-	337	Protein_2407	DUF5615 family PIN-like protein	-
NOS7107_RS12170	2862537..2862761	-	225	WP_172641463.1	DUF433 domain-containing protein	-
NOS7107_RS12175	2863163..2864689	+	1527	WP_015113276.1	ferredoxin:protochlorophyllide reductase (ATP-dependent) subunit B	-
NOS7107_RS12180	2864794..2865498	+	705	WP_015113277.1	ribonuclease III family protein	-
NOS7107_RS12185	2865706..2865996	+	291	WP_015113278.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
NOS7107_RS12190	2865977..2866276	+	300	WP_015113279.1	Txe/YoeB family addiction module toxin	Toxin
NOS7107_RS12195	2866687..2869788	+	3102	WP_015113280.1	DUF3854 domain-containing protein	-
NOS7107_RS12200	2869777..2870934	-	1158	WP_044500759.1	beta-ketoacyl-ACP synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (20-99)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-74)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11942.51 Da
• Isoelectric Point: 7.2005

>T28495 WP_015113279.1 NC_019676:2865977-2866276 [Nostoc sp. PCC 7107]
MAKKKNETQPQENKARDAVFHPEFREDLVYWIETNRKTALRAFDLIESIMRDPFSGIGKPEPLKYLDSDAWSRRLTQEYR
IVYLVSDDRIDFLQARYHY

Nucleotide

• Length: 300 bp

>T28495 NC_019676:2865977-2866276 [Nostoc sp. PCC 7107]
TTGGCGAAGAAGAAGAATGAAACCCAACCTCAAGAAAATAAAGCCAGAGATGCTGTGTTCCATCCAGAATTCAGAGAAGA
CCTTGTTTATTGGATTGAAACAAACCGAAAAACTGCGCTTCGTGCTTTTGATTTGATTGAATCGATTATGCGAGATCCTT
TTTCAGGAATTGGTAAACCTGAACCATTGAAATACTTGGATTCAGATGCGTGGTCACGACGACTTACTCAAGAATATCGT
ATTGTTTATCTAGTAAGTGATGACCGGATTGATTTTCTTCAAGCTCGATATCACTACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10737.08 Da
• Isoelectric Point: 4.1743

>AT28495 WP_015113278.1 NC_019676:2865706-2865996 [Nostoc sp. PCC 7107]
MSNQTNLTDACNNLAELCEQVVVDRDVVIINRQEGESVALIAVDELNSLLETSYLLRSPKNAERLLTALERAKARTLKPQ
SINELRQELGIGEEEE

Nucleotide

• Length: 291 bp

>AT28495 NC_019676:2865706-2865996 [Nostoc sp. PCC 7107]
ATGTCCAATCAGACAAACTTAACTGATGCTTGTAATAACCTAGCCGAACTCTGCGAGCAAGTAGTTGTAGATAGAGATGT
AGTAATTATTAATCGCCAAGAAGGTGAAAGTGTTGCTTTAATTGCTGTTGATGAACTAAACAGTTTATTAGAAACATCTT
ATTTACTTCGCTCACCTAAAAATGCAGAACGACTATTAACTGCTTTAGAAAGAGCAAAAGCAAGAACTTTAAAACCGCAA
AGTATAAACGAACTGCGTCAGGAGTTGGGTATTGGCGAAGAAGAAGAATGA

Structures

Toxin

• AlphaFold DB: K9QDA6

Antitoxin

• AlphaFold DB: K9QCG7