Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786732..787389 Replicon chromosome
Accession NZ_FO834906
Organism Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag BN49_RS05110 Protein ID WP_002916310.1
Coordinates 786979..787389 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag BN49_RS05105 Protein ID WP_002916312.1
Coordinates 786732..786998 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN49_RS05080 781940..783373 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
BN49_RS05085 783492..784220 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
BN49_RS05090 784270..784581 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
BN49_RS05095 784745..785404 + 660 WP_002916317.1 hemolysin III family protein -
BN49_RS05100 785503..786486 - 984 WP_016530681.1 tRNA-modifying protein YgfZ -
BN49_RS05105 786732..786998 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
BN49_RS05110 786979..787389 + 411 WP_002916310.1 protein YgfX Toxin
BN49_RS05115 787396..787917 - 522 WP_004144730.1 flavodoxin FldB -
BN49_RS05120 788018..788914 + 897 WP_046042376.1 site-specific tyrosine recombinase XerD -
BN49_RS05125 788937..789650 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BN49_RS05130 789656..791389 + 1734 WP_016530103.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T284929 WP_002916310.1 NZ_FO834906:786979-787389 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT284929 WP_002916312.1 NZ_FO834906:786732-786998 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References