Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 358530..359176 Replicon chromosome
Accession NZ_FO834906
Organism Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag BN49_RS02820 Protein ID WP_016529833.1
Coordinates 358530..358877 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W9BB18
Locus tag BN49_RS02825 Protein ID WP_016529832.1
Coordinates 358877..359176 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN49_RS02810 354456..355889 + 1434 WP_002920564.1 glycogen synthase GlgA -
BN49_RS02815 355907..358354 + 2448 WP_002920561.1 glycogen phosphorylase -
BN49_RS02820 358530..358877 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BN49_RS02825 358877..359176 + 300 WP_016529832.1 helix-turn-helix domain-containing protein Antitoxin
BN49_RS02830 359239..360747 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
BN49_RS02835 360952..361281 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
BN49_RS02840 361332..362162 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
BN49_RS02845 362212..362970 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T284927 WP_016529833.1 NZ_FO834906:358530-358877 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.63 Da        Isoelectric Point: 10.4041

>AT284927 WP_016529832.1 NZ_FO834906:358877-359176 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNAPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB W9BB18

References