Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 69571..70214 Replicon plasmid I
Accession NZ_FO834904
Organism Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag BN49_RS00410 Protein ID WP_001044768.1
Coordinates 69571..69987 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag BN49_RS00415 Protein ID WP_001261287.1
Coordinates 69984..70214 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN49_RS00375 64665..64919 - 255 WP_016528790.1 hypothetical protein -
BN49_RS00380 64995..65252 - 258 WP_004098928.1 hypothetical protein -
BN49_RS00385 65301..65504 - 204 WP_004150739.1 hemolysin expression modulator Hha -
BN49_RS00390 65565..66059 - 495 WP_016528789.1 hypothetical protein -
BN49_RS00395 66090..66656 - 567 WP_009654312.1 hypothetical protein -
BN49_RS00400 66653..66916 - 264 WP_009310051.1 hypothetical protein -
BN49_RS00405 67271..69409 + 2139 WP_000350635.1 AAA family ATPase -
BN49_RS00410 69571..69987 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
BN49_RS00415 69984..70214 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BN49_RS00420 70520..73639 + 3120 WP_032446663.1 hypothetical protein -
BN49_RS00425 73902..75035 + 1134 WP_000545983.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - clbI / basG 1..95087 95087


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T284920 WP_001044768.1 NZ_FO834904:c69987-69571 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT284920 WP_001261287.1 NZ_FO834904:c70214-69984 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References