Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 4053494..4054377 Replicon chromosome
Accession NZ_CP128540
Organism Pseudomonas alloputida strain NMI24_14

Toxin (Protein)


Gene name - Uniprot ID Q88K57
Locus tag LU682_RS18810 Protein ID WP_003250527.1
Coordinates 4053494..4053931 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID I7C3Q7
Locus tag LU682_RS18815 Protein ID WP_003250525.1
Coordinates 4053928..4054377 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU682_RS18785 (LU682_018785) 4049038..4049427 - 390 WP_049587628.1 hypothetical protein -
LU682_RS18790 (LU682_018790) 4049430..4049678 - 249 Protein_3700 PAAR domain-containing protein -
LU682_RS18795 (LU682_018795) 4049842..4051071 - 1230 WP_049587623.1 acyl-CoA dehydrogenase -
LU682_RS18800 (LU682_018800) 4051212..4052138 + 927 WP_010953387.1 LysR family transcriptional regulator -
LU682_RS18805 (LU682_018805) 4052332..4053486 + 1155 WP_049587669.1 aminotransferase class V-fold PLP-dependent enzyme -
LU682_RS18810 (LU682_018810) 4053494..4053931 - 438 WP_003250527.1 RES family NAD+ phosphorylase Toxin
LU682_RS18815 (LU682_018815) 4053928..4054377 - 450 WP_003250525.1 DUF2384 domain-containing protein Antitoxin
LU682_RS18820 (LU682_018820) 4054520..4055173 - 654 WP_010953384.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
LU682_RS18825 (LU682_018825) 4055277..4056200 + 924 WP_010953383.1 LysR family transcriptional regulator -
LU682_RS18830 (LU682_018830) 4056249..4057079 + 831 WP_003250518.1 AraC family transcriptional regulator -
LU682_RS18835 (LU682_018835) 4057130..4057714 + 585 WP_010953382.1 LysE family transporter -
LU682_RS18840 (LU682_018840) 4057754..4058953 - 1200 WP_049587621.1 sugar transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15990.29 Da        Isoelectric Point: 5.6007

>T284835 WP_003250527.1 NZ_CP128540:c4053931-4053494 [Pseudomonas alloputida]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAQPELTRTLGNRFLDDCSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Download         Length: 438 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16956.46 Da        Isoelectric Point: 5.7258

>AT284835 WP_003250525.1 NZ_CP128540:c4054377-4053928 [Pseudomonas alloputida]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6GW6

Antitoxin

Source ID Structure
AlphaFold DB I7C3Q7

References