Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 244858..245494 Replicon chromosome
Accession NZ_CP128459
Organism Geobacillus stearothermophilus strain EF60134

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag QT238_RS01280 Protein ID WP_003253417.1
Coordinates 245144..245494 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A087LE06
Locus tag QT238_RS01275 Protein ID WP_033010302.1
Coordinates 244858..245139 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QT238_RS01255 (QT238_01255) 241109..241726 - 618 WP_289668350.1 rhomboid family intramembrane serine protease -
QT238_RS01260 (QT238_01260) 241846..242235 + 390 WP_033010299.1 holo-ACP synthase -
QT238_RS01265 (QT238_01265) 242315..243334 + 1020 WP_277391990.1 outer membrane lipoprotein carrier protein LolA -
QT238_RS01270 (QT238_01270) 243577..244743 + 1167 WP_033010307.1 alanine racemase -
QT238_RS01275 (QT238_01275) 244858..245139 + 282 WP_033010302.1 hypothetical protein Antitoxin
QT238_RS01280 (QT238_01280) 245144..245494 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QT238_RS01285 (QT238_01285) 246037..248199 + 2163 WP_289668351.1 Tex family protein -
QT238_RS01290 (QT238_01290) 248257..248370 - 114 WP_094239478.1 cortex morphogenetic protein CmpA -
QT238_RS01295 (QT238_01295) 248464..248925 + 462 WP_033016555.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T284579 WP_003253417.1 NZ_CP128459:245144-245494 [Geobacillus stearothermophilus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10683.20 Da        Isoelectric Point: 7.2027

>AT284579 WP_033010302.1 NZ_CP128459:244858-245139 [Geobacillus stearothermophilus]
VSESGATTEIIVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A087LE06

References