Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 231602..232238 Replicon chromosome
Accession NZ_CP128453
Organism Geobacillus stearothermophilus strain EF60045

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag QT235_RS01255 Protein ID WP_003253417.1
Coordinates 231888..232238 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A087LE06
Locus tag QT235_RS01250 Protein ID WP_033010302.1
Coordinates 231602..231883 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QT235_RS01230 (QT235_01230) 227854..228471 - 618 WP_289643528.1 rhomboid family intramembrane serine protease -
QT235_RS01235 (QT235_01235) 228590..228979 + 390 WP_289643530.1 holo-ACP synthase -
QT235_RS01240 (QT235_01240) 229059..230078 + 1020 WP_289643531.1 outer membrane lipoprotein carrier protein LolA -
QT235_RS01245 (QT235_01245) 230321..231487 + 1167 WP_033010307.1 alanine racemase -
QT235_RS01250 (QT235_01250) 231602..231883 + 282 WP_033010302.1 hypothetical protein Antitoxin
QT235_RS01255 (QT235_01255) 231888..232238 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QT235_RS01260 (QT235_01260) 232782..234944 + 2163 WP_033010303.1 Tex family protein -
QT235_RS01265 (QT235_01265) 235002..235115 - 114 WP_089135018.1 cortex morphogenetic protein CmpA -
QT235_RS01270 (QT235_01270) 235207..235668 + 462 WP_033010304.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T284572 WP_003253417.1 NZ_CP128453:231888-232238 [Geobacillus stearothermophilus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10683.20 Da        Isoelectric Point: 7.2027

>AT284572 WP_033010302.1 NZ_CP128453:231602-231883 [Geobacillus stearothermophilus]
VSESGATTEIIVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A087LE06

References