Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4068301..4068953 Replicon chromosome
Accession NZ_CP127881
Organism Serratia marcescens strain ELP1.10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QRD25_RS19380 Protein ID WP_004931830.1
Coordinates 4068301..4068645 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag QRD25_RS19385 Protein ID WP_004931828.1
Coordinates 4068651..4068953 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD25_RS19370 (QRD25_19375) 4064643..4066901 - 2259 WP_286093559.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
QRD25_RS19375 (QRD25_19380) 4067122..4068141 + 1020 WP_004931832.1 HTH-type transcriptional regulator GalR -
QRD25_RS19380 (QRD25_19385) 4068301..4068645 + 345 WP_004931830.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRD25_RS19385 (QRD25_19390) 4068651..4068953 + 303 WP_004931828.1 XRE family transcriptional regulator Antitoxin
QRD25_RS19390 (QRD25_19395) 4068981..4070243 - 1263 WP_021505676.1 diaminopimelate decarboxylase -
QRD25_RS19395 (QRD25_19400) 4070377..4071300 + 924 WP_286093560.1 LysR family transcriptional regulator -
QRD25_RS19400 (QRD25_19405) 4071328..4072236 - 909 WP_015378928.1 LysR family transcriptional regulator -
QRD25_RS19405 (QRD25_19410) 4072345..4073229 + 885 WP_004931820.1 MBL fold metallo-hydrolase -
QRD25_RS19410 (QRD25_19415) 4073304..4073951 + 648 WP_004931818.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13383.44 Da        Isoelectric Point: 10.6087

>T284342 WP_004931830.1 NZ_CP127881:4068301-4068645 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT284342 WP_004931828.1 NZ_CP127881:4068651-4068953 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References