Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 19551..20152 Replicon chromosome
Accession NZ_CP127881
Organism Serratia marcescens strain ELP1.10

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0Q8I8
Locus tag QRD25_RS00100 Protein ID WP_004933929.1
Coordinates 19551..19931 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag QRD25_RS00105 Protein ID WP_004933932.1
Coordinates 19931..20152 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD25_RS00075 (QRD25_00075) 14797..16077 + 1281 WP_004933910.1 DUF3748 domain-containing protein -
QRD25_RS00080 (QRD25_00080) 16108..16455 - 348 WP_004933911.1 YceK/YidQ family lipoprotein -
QRD25_RS00085 (QRD25_00085) 16765..17178 + 414 WP_004933919.1 small heat shock chaperone IbpA -
QRD25_RS00090 (QRD25_00090) 17286..17714 + 429 WP_004933922.1 small heat shock chaperone IbpB -
QRD25_RS00095 (QRD25_00095) 17882..19540 + 1659 WP_131165267.1 putative transporter -
QRD25_RS00100 (QRD25_00100) 19551..19931 - 381 WP_004933929.1 type II toxin-antitoxin system VapC family toxin Toxin
QRD25_RS00105 (QRD25_00105) 19931..20152 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
QRD25_RS00110 (QRD25_00110) 20227..21477 - 1251 WP_004933935.1 valine--pyruvate transaminase -
QRD25_RS00115 (QRD25_00115) 21613..23676 - 2064 WP_286093686.1 alpha-amylase -
QRD25_RS00120 (QRD25_00120) 23872..24024 + 153 WP_015376155.1 hypothetical protein -
QRD25_RS00125 (QRD25_00125) 24026..25003 - 978 WP_197753766.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14173.48 Da        Isoelectric Point: 7.3170

>T284331 WP_004933929.1 NZ_CP127881:c19931-19551 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHTNPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT284331 WP_004933932.1 NZ_CP127881:c20152-19931 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0Q8I8

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References