Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 856328..856985 Replicon chromosome
Accession NZ_CP127873
Organism Klebsiella michiganensis strain ELP1.34B

Toxin (Protein)


Gene name cptA Uniprot ID A0A6P1V2U3
Locus tag QRD21_RS04095 Protein ID WP_046876661.1
Coordinates 856575..856985 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag QRD21_RS04090 Protein ID WP_004124953.1
Coordinates 856328..856594 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD21_RS04075 (QRD21_04075) 851562..851987 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
QRD21_RS04080 (QRD21_04080) 852108..854906 - 2799 WP_286115458.1 transcriptional regulator DagR -
QRD21_RS04085 (QRD21_04085) 855100..856083 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
QRD21_RS04090 (QRD21_04090) 856328..856594 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
QRD21_RS04095 (QRD21_04095) 856575..856985 + 411 WP_046876661.1 protein YgfX Toxin
QRD21_RS04100 (QRD21_04100) 856994..857515 - 522 WP_014226792.1 flavodoxin FldB -
QRD21_RS04105 (QRD21_04105) 857637..858533 + 897 WP_046876662.1 site-specific tyrosine recombinase XerD -
QRD21_RS04110 (QRD21_04110) 858556..859269 + 714 WP_046876663.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRD21_RS04115 (QRD21_04115) 859275..861008 + 1734 WP_046876664.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16074.91 Da        Isoelectric Point: 10.9455

>T284320 WP_046876661.1 NZ_CP127873:856575-856985 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT284320 WP_004124953.1 NZ_CP127873:856328-856594 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V2U3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References