Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2317600..2318102 Replicon chromosome
Accession NZ_CP127314
Organism Escherichia coli strain C25

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QRM69_RS11025 Protein ID WP_000767822.1
Coordinates 2317848..2318102 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QRM69_RS11020 Protein ID WP_001259255.1
Coordinates 2317600..2317851 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM69_RS10995 (2312778) 2312778..2313845 - 1068 WP_286005157.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QRM69_RS11000 (2313845) 2313845..2314915 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
QRM69_RS11005 (2314912) 2314912..2316216 - 1305 WP_001297912.1 histidinol dehydrogenase -
QRM69_RS11010 (2316222) 2316222..2317121 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QRM69_RS11015 (2317267) 2317267..2317317 - 51 WP_001364200.1 his operon leader peptide -
QRM69_RS11020 (2317600) 2317600..2317851 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QRM69_RS11025 (2317848) 2317848..2318102 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QRM69_RS11030 (2318185) 2318185..2319009 + 825 WP_000754733.1 SDR family oxidoreductase -
QRM69_RS11035 (2319055) 2319055..2319984 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QRM69_RS11040 (2320198) 2320198..2320260 + 63 WP_010723108.1 membrane protein YoeI -
QRM69_RS11045 (2320250) 2320250..2321608 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T284141 WP_000767822.1 NZ_CP127314:2317848-2318102 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT284141 WP_001259255.1 NZ_CP127314:2317600-2317851 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References