Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 443859..444870 Replicon chromosome
Accession NZ_CP127277
Organism Mycobacterium tuberculosis strain 25421

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag QRF07_RS01930 Protein ID WP_003401859.1
Coordinates 443859..444452 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag QRF07_RS01935 Protein ID WP_003401860.1
Coordinates 444481..444870 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF07_RS01910 (QRF07_01910) 439508..440890 + 1383 WP_003898415.1 magnesium transporter -
QRF07_RS01915 (QRF07_01915) 440902..441936 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
QRF07_RS01920 (QRF07_01920) 442032..442715 + 684 WP_003401857.1 VTT domain-containing protein -
QRF07_RS01925 (QRF07_01925) 442704..443834 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
QRF07_RS01930 (QRF07_01930) 443859..444452 - 594 WP_003401859.1 zeta toxin family protein Toxin
QRF07_RS01935 (QRF07_01935) 444481..444870 - 390 WP_003401860.1 hypothetical protein Antitoxin
QRF07_RS01940 (QRF07_01940) 444951..446162 - 1212 WP_003401861.1 VWA domain-containing protein -
QRF07_RS01945 (QRF07_01945) 446168..446770 - 603 WP_003898417.1 SRPBCC family protein -
QRF07_RS01950 (QRF07_01950) 446784..447680 - 897 WP_003898418.1 MoxR family ATPase -
QRF07_RS01955 (QRF07_01955) 447677..448270 - 594 WP_003401864.1 NTP transferase domain-containing protein -
QRF07_RS01960 (QRF07_01960) 448267..449022 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T283993 WP_003401859.1 NZ_CP127277:c444452-443859 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT283993 WP_003401860.1 NZ_CP127277:c444870-444481 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References