Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 443859..444870 | Replicon | chromosome |
| Accession | NZ_CP127277 | ||
| Organism | Mycobacterium tuberculosis strain 25421 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | L7N5R2 |
| Locus tag | QRF07_RS01930 | Protein ID | WP_003401859.1 |
| Coordinates | 443859..444452 (-) | Length | 198 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | O53702 |
| Locus tag | QRF07_RS01935 | Protein ID | WP_003401860.1 |
| Coordinates | 444481..444870 (-) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QRF07_RS01910 (QRF07_01910) | 439508..440890 | + | 1383 | WP_003898415.1 | magnesium transporter | - |
| QRF07_RS01915 (QRF07_01915) | 440902..441936 | - | 1035 | WP_003401856.1 | class II fructose-bisphosphate aldolase | - |
| QRF07_RS01920 (QRF07_01920) | 442032..442715 | + | 684 | WP_003401857.1 | VTT domain-containing protein | - |
| QRF07_RS01925 (QRF07_01925) | 442704..443834 | - | 1131 | WP_003401858.1 | glycoside hydrolase family 76 protein | - |
| QRF07_RS01930 (QRF07_01930) | 443859..444452 | - | 594 | WP_003401859.1 | zeta toxin family protein | Toxin |
| QRF07_RS01935 (QRF07_01935) | 444481..444870 | - | 390 | WP_003401860.1 | hypothetical protein | Antitoxin |
| QRF07_RS01940 (QRF07_01940) | 444951..446162 | - | 1212 | WP_003401861.1 | VWA domain-containing protein | - |
| QRF07_RS01945 (QRF07_01945) | 446168..446770 | - | 603 | WP_003898417.1 | SRPBCC family protein | - |
| QRF07_RS01950 (QRF07_01950) | 446784..447680 | - | 897 | WP_003898418.1 | MoxR family ATPase | - |
| QRF07_RS01955 (QRF07_01955) | 447677..448270 | - | 594 | WP_003401864.1 | NTP transferase domain-containing protein | - |
| QRF07_RS01960 (QRF07_01960) | 448267..449022 | - | 756 | WP_003401865.1 | XdhC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 198 a.a. Molecular weight: 21344.53 Da Isoelectric Point: 10.5018
>T283993 WP_003401859.1 NZ_CP127277:c444452-443859 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
Download Length: 594 bp
Antitoxin
Download Length: 130 a.a. Molecular weight: 13648.21 Da Isoelectric Point: 6.0829
>AT283993 WP_003401860.1 NZ_CP127277:c444870-444481 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
Download Length: 390 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BRU8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BRT0 |