Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3746161..3746690 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag QRF09_RS17665 Protein ID WP_003417760.1
Coordinates 3746433..3746690 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag QRF09_RS17660 Protein ID WP_003417757.1
Coordinates 3746161..3746436 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS17625 (QRF09_17625) 3742734..3743423 - 690 WP_003917774.1 BBE domain-containing protein -
QRF09_RS17630 (QRF09_17630) 3743610..3743981 - 372 WP_003417739.1 FAD-binding protein -
QRF09_RS17635 (QRF09_17635) 3743879..3744097 - 219 WP_157132559.1 hypothetical protein -
QRF09_RS17640 (QRF09_17640) 3744124..3744384 - 261 WP_003417741.1 hypothetical protein -
QRF09_RS17645 (QRF09_17645) 3744499..3744888 + 390 WP_003417745.1 DUF732 domain-containing protein -
QRF09_RS17650 (QRF09_17650) 3744902..3745195 - 294 WP_003417749.1 DUF3017 domain-containing protein -
QRF09_RS17655 (QRF09_17655) 3745192..3746037 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
QRF09_RS17660 (QRF09_17660) 3746161..3746436 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
QRF09_RS17665 (QRF09_17665) 3746433..3746690 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
QRF09_RS17670 (QRF09_17670) 3746732..3747922 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
QRF09_RS17675 (QRF09_17675) 3748039..3748407 + 369 WP_003417765.1 FHA domain-containing protein -
QRF09_RS17680 (QRF09_17680) 3748404..3748955 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
QRF09_RS17685 (QRF09_17685) 3748962..3749543 - 582 WP_003417769.1 ATP/GTP-binding protein -
QRF09_RS17690 (QRF09_17690) 3749524..3749892 - 369 WP_003417772.1 DUF742 domain-containing protein -
QRF09_RS17695 (QRF09_17695) 3749870..3750262 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T283925 WP_003417760.1 NZ_CP127275:3746433-3746690 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT283925 WP_003417757.1 NZ_CP127275:3746161-3746436 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References