Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2833376..2834016 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag QRF09_RS13310 Protein ID WP_003412970.1
Coordinates 2833376..2833795 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag QRF09_RS13315 Protein ID WP_003412975.1
Coordinates 2833792..2834016 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS13280 (QRF09_13280) 2828961..2829683 - 723 WP_003412957.1 DUF1906 domain-containing protein -
QRF09_RS13285 (QRF09_13285) 2830200..2830427 + 228 WP_285978956.1 type II toxin-antitoxin system VapB family antitoxin -
QRF09_RS13290 (QRF09_13290) 2830424..2830825 + 402 WP_003412963.1 PIN domain-containing protein -
QRF09_RS13295 (QRF09_13295) 2830860..2831780 - 921 WP_003412965.1 restriction endonuclease -
QRF09_RS13300 (QRF09_13300) 2832121..2832366 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
QRF09_RS13305 (QRF09_13305) 2832425..2833375 + 951 WP_003911916.1 ERCC4 domain-containing protein -
QRF09_RS13310 (QRF09_13310) 2833376..2833795 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF09_RS13315 (QRF09_13315) 2833792..2834016 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
QRF09_RS13320 (QRF09_13320) 2834047..2836890 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
QRF09_RS13325 (QRF09_13325) 2836962..2837363 - 402 WP_003412981.1 hypothetical protein -
QRF09_RS13330 (QRF09_13330) 2837363..2837833 - 471 WP_003899364.1 transcription antitermination factor NusB -
QRF09_RS13335 (QRF09_13335) 2837836..2838399 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T283910 WP_003412970.1 NZ_CP127275:c2833795-2833376 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT283910 WP_003412975.1 NZ_CP127275:c2834016-2833792 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References