Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2787192..2787844 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag QRF09_RS13115 Protein ID WP_003905869.1
Coordinates 2787419..2787844 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag QRF09_RS13110 Protein ID WP_003412749.1
Coordinates 2787192..2787413 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS13095 (QRF09_13095) 2785432..2785638 - 207 WP_003899347.1 hypothetical protein -
QRF09_RS13100 (QRF09_13100) 2785774..2786397 + 624 WP_003900858.1 TIGR00725 family protein -
QRF09_RS13105 (QRF09_13105) 2786387..2787139 + 753 WP_003901416.1 hypothetical protein -
QRF09_RS13110 (QRF09_13110) 2787192..2787413 + 222 WP_003412749.1 antitoxin Antitoxin
QRF09_RS13115 (QRF09_13115) 2787419..2787844 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
QRF09_RS13120 (QRF09_13120) 2787867..2789048 - 1182 WP_003905870.1 dihydrolipoamide acetyltransferase family protein -
QRF09_RS13125 (QRF09_13125) 2789045..2790091 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
QRF09_RS13130 (QRF09_13130) 2790102..2791205 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
QRF09_RS13135 (QRF09_13135) 2791464..2792285 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
QRF09_RS13140 (QRF09_13140) 2792282..2792839 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T283909 WP_003905869.1 NZ_CP127275:2787419-2787844 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT283909 WP_003412749.1 NZ_CP127275:2787192-2787413 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References