Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1226973..1227604 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag QRF09_RS05875 Protein ID WP_003405820.1
Coordinates 1226973..1227284 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag QRF09_RS05880 Protein ID WP_003405836.1
Coordinates 1227284..1227604 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS05855 (QRF09_05855) 1222454..1223878 - 1425 WP_003405805.1 class II fumarate hydratase -
QRF09_RS05860 (QRF09_05860) 1223909..1224997 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
QRF09_RS05865 (QRF09_05865) 1225053..1225697 + 645 WP_003915494.1 DUF4245 domain-containing protein -
QRF09_RS05870 (QRF09_05870) 1225704..1226861 - 1158 WP_003898727.1 AI-2E family transporter -
QRF09_RS05875 (QRF09_05875) 1226973..1227284 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
QRF09_RS05880 (QRF09_05880) 1227284..1227604 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
QRF09_RS05885 (QRF09_05885) 1227614..1229150 + 1537 Protein_1159 carboxylesterase/lipase family protein -
QRF09_RS05890 (QRF09_05890) 1229157..1230269 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
QRF09_RS05895 (QRF09_05895) 1230279..1230536 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
QRF09_RS05900 (QRF09_05900) 1230526..1231773 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
QRF09_RS05905 (QRF09_05905) 1231770..1232408 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T283888 WP_003405820.1 NZ_CP127275:c1227284-1226973 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT283888 WP_003405836.1 NZ_CP127275:c1227604-1227284 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References