Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1011009..1011628 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag QRF09_RS04800 Protein ID WP_003404726.1
Coordinates 1011194..1011628 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag QRF09_RS04795 Protein ID WP_003898641.1
Coordinates 1011009..1011188 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS04780 (QRF09_04780) 1006483..1008062 + 1580 Protein_942 serine hydrolase -
QRF09_RS04785 (QRF09_04785) 1008059..1010452 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
QRF09_RS04790 (QRF09_04790) 1010725..1010883 + 159 WP_003404720.1 hypothetical protein -
QRF09_RS04795 (QRF09_04795) 1011009..1011188 + 180 WP_003898641.1 antitoxin Antitoxin
QRF09_RS04800 (QRF09_04800) 1011194..1011628 + 435 WP_003404726.1 SRPBCC family protein Toxin
QRF09_RS04805 (QRF09_04805) 1011726..1012499 + 774 WP_003404735.1 VOC family protein -
QRF09_RS04810 (QRF09_04810) 1012564..1013013 + 450 WP_003404738.1 hypothetical protein -
QRF09_RS04815 (QRF09_04815) 1013148..1013378 - 231 WP_003898642.1 hypothetical protein -
QRF09_RS04820 (QRF09_04820) 1013545..1015053 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
QRF09_RS04825 (QRF09_04825) 1015055..1016293 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T283885 WP_003404726.1 NZ_CP127275:1011194-1011628 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT283885 WP_003898641.1 NZ_CP127275:1011009-1011188 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References