Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 712927..713576 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag QRF09_RS03265 Protein ID WP_003403236.1
Coordinates 713181..713576 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag QRF09_RS03260 Protein ID WP_003403235.1
Coordinates 712927..713181 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS03235 (QRF09_03235) 708053..708136 + 84 Protein_641 galactose-1-phosphate uridylyltransferase -
QRF09_RS03240 (QRF09_03240) 708155..709236 + 1082 Protein_642 galactose-1-phosphate uridylyltransferase -
QRF09_RS03245 (QRF09_03245) 709233..710324 + 1092 WP_003900977.1 galactokinase -
QRF09_RS03250 (QRF09_03250) 710719..711783 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
QRF09_RS03255 (QRF09_03255) 711887..712834 + 948 WP_003403232.1 DUF732 domain-containing protein -
QRF09_RS03260 (QRF09_03260) 712927..713181 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
QRF09_RS03265 (QRF09_03265) 713181..713576 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
QRF09_RS03270 (QRF09_03270) 713670..714410 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
QRF09_RS03275 (QRF09_03275) 714542..714802 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QRF09_RS03280 (QRF09_03280) 714799..715206 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
QRF09_RS03285 (QRF09_03285) 715278..716429 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
QRF09_RS03290 (QRF09_03290) 716522..718249 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T283878 WP_003403236.1 NZ_CP127275:713181-713576 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT283878 WP_003403235.1 NZ_CP127275:712927-713181 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References