Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 360451..361094 Replicon chromosome
Accession NZ_CP127275
Organism Mycobacterium tuberculosis strain 6721

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag QRF09_RS01570 Protein ID WP_003401566.1
Coordinates 360669..361094 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag QRF09_RS01565 Protein ID WP_003401563.1
Coordinates 360451..360672 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF09_RS01540 (QRF09_01540) 355570..356373 - 804 WP_003401540.1 Stf0 family sulphotransferase -
QRF09_RS01545 (QRF09_01545) 356383..357780 - 1398 WP_003401544.1 sulfatase -
QRF09_RS01550 (QRF09_01550) 357959..359734 + 1776 WP_010886074.1 PE family protein -
QRF09_RS01555 (QRF09_01555) 359877..360104 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
QRF09_RS01560 (QRF09_01560) 360101..360403 + 303 WP_003401560.1 toxin-antitoxin system toxin -
QRF09_RS01565 (QRF09_01565) 360451..360672 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
QRF09_RS01570 (QRF09_01570) 360669..361094 + 426 WP_003401566.1 PIN domain nuclease Toxin
QRF09_RS01575 (QRF09_01575) 361230..361862 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
QRF09_RS01580 (QRF09_01580) 361859..362767 + 909 WP_003900117.1 protochlorophyllide reductase -
QRF09_RS01585 (QRF09_01585) 362775..363365 - 591 WP_229298012.1 hypothetical protein -
QRF09_RS01590 (QRF09_01590) 363358..363408 - 51 Protein_314 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T283870 WP_003401566.1 NZ_CP127275:360669-361094 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT283870 WP_003401563.1 NZ_CP127275:360451-360672 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References