Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 3116686..3118460 Replicon chromosome
Accession NZ_CP127273
Organism Mycobacterium tuberculosis strain 3320

Toxin (Protein)


Gene name abiEi Uniprot ID P71626
Locus tag QQ046_RS14860 Protein ID WP_003414409.1
Coordinates 3116686..3117570 (-) Length 295 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID P71625
Locus tag QQ046_RS14865 Protein ID WP_003414414.1
Coordinates 3117573..3118460 (-) Length 296 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ046_RS14840 (QQ046_14840) 3111950..3112324 - 375 WP_003414296.1 type III-A CRISPR-associated protein Csm2 -
QQ046_RS14845 (QQ046_14845) 3112321..3114750 - 2430 WP_003911999.1 type III-A CRISPR-associated protein Cas10/Csm1 -
QQ046_RS14850 (QQ046_14850) 3114747..3115535 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
QQ046_RS14855 (QQ046_14855) 3115869..3116414 - 546 WP_014584866.1 DUF1802 family protein -
QQ046_RS14860 (QQ046_14860) 3116686..3117570 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QQ046_RS14865 (QQ046_14865) 3117573..3118460 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
QQ046_RS14870 (QQ046_14870) 3118765..3119310 - 546 WP_003910939.1 DUF1802 family protein -
QQ046_RS14875 (QQ046_14875) 3119307..3119576 - 270 WP_003414489.1 DUF2277 family protein -
QQ046_RS14880 (QQ046_14880) 3119597..3119989 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin -
QQ046_RS14885 (QQ046_14885) 3119986..3120201 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
QQ046_RS14890 (QQ046_14890) 3120248..3120997 + 750 WP_003902358.1 enoyl-CoA hydratase -
QQ046_RS14895 (QQ046_14895) 3121076..3122158 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 33056.72 Da        Isoelectric Point: 7.1520

>T283798 WP_003414409.1 NZ_CP127273:c3117570-3116686 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS

Download         Length: 885 bp

Antitoxin


Download         Length: 296 a.a.        Molecular weight: 32315.19 Da        Isoelectric Point: 9.4723

>AT283798 WP_003414414.1 NZ_CP127273:c3118460-3117573 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Download         Length: 888 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6Y56

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBU9

References