Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5006..5559 Replicon plasmid pQ501
Accession NZ_CP127256
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag QQ972_RS24070 Protein ID WP_000421257.1
Coordinates 5284..5559 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QQ972_RS24065 Protein ID WP_019842653.1
Coordinates 5006..5284 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS24035 (176) 176..439 - 264 Protein_1 hypothetical protein -
QQ972_RS24040 (473) 473..1018 + 546 Protein_2 hypothetical protein -
QQ972_RS24045 (1300) 1300..3180 + 1881 WP_125094062.1 colicin Ia central receptor-binding domain-containing protein -
QQ972_RS24050 (3198) 3198..3545 - 348 WP_001595228.1 colicin E1 family microcin immunity protein -
QQ972_RS24055 (3664) 3664..4011 + 348 WP_019842650.1 DUF6404 family protein -
QQ972_RS24060 (4133) 4133..4919 + 787 Protein_6 IS21 family transposase -
QQ972_RS24065 (5006) 5006..5284 + 279 WP_019842653.1 ribbon-helix-helix domain-containing protein Antitoxin
QQ972_RS24070 (5284) 5284..5559 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQ972_RS24075 (5665) 5665..5868 + 204 Protein_9 hypothetical protein -
QQ972_RS24080 (6385) 6385..6621 + 237 WP_137498364.1 colicin V immunity protein -
QQ972_RS24085 (6625) 6625..6750 - 126 Protein_11 efflux transporter periplasmic adaptor subunit -
QQ972_RS24090 (7075) 7075..8024 + 950 Protein_12 omptin family outer membrane protease -
QQ972_RS24095 (8209) 8209..9693 + 1485 WP_285985033.1 alpha/beta hydrolase -
QQ972_RS24100 (10158) 10158..10418 + 261 WP_019842660.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / iroN / iroE / iroD / iroC / iroB / papH / papC / papD / vat / vat / afaC-I 1..137541 137541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T283739 WP_000421257.1 NZ_CP127256:5284-5559 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp


Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10225.59 Da        Isoelectric Point: 5.6558

>AT283739 WP_019842653.1 NZ_CP127256:5006-5284 [Escherichia coli]
MKNNTAQATKVITAHVPLPMADKVDQIAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQIIDHQAVQAWAD
SLSTDNPLPVPR

Download         Length: 279 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PMX5


Antitoxin

Source ID Structure

References