Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1926562..1927369 Replicon chromosome
Accession NZ_CP127255
Organism Escherichia coli strain Q5

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E2S9W0
Locus tag QQ972_RS09225 Protein ID WP_042004473.1
Coordinates 1926562..1926948 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag QQ972_RS09230 Protein ID WP_001285482.1
Coordinates 1926995..1927369 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ972_RS09200 (1921929) 1921929..1923522 + 1594 Protein_1784 IS66 family transposase -
QQ972_RS09205 (1923670) 1923670..1924658 + 989 Protein_1785 IS630 family transposase -
QQ972_RS09210 (1924737) 1924737..1925145 - 409 Protein_1786 DUF5983 family protein -
QQ972_RS09220 (1926479) 1926479..1926565 - 87 Protein_1788 DUF5983 family protein -
QQ972_RS09225 (1926562) 1926562..1926948 - 387 WP_042004473.1 TA system toxin CbtA family protein Toxin
QQ972_RS09230 (1926995) 1926995..1927369 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QQ972_RS09235 (1927419) 1927419..1928063 - 645 WP_000086759.1 hypothetical protein -
QQ972_RS09240 (1928081) 1928081..1928302 - 222 WP_000692315.1 DUF987 domain-containing protein -
QQ972_RS09245 (1928365) 1928365..1928841 - 477 WP_001186181.1 RadC family protein -
QQ972_RS09250 (1928857) 1928857..1929330 - 474 WP_001313575.1 antirestriction protein -
QQ972_RS09255 (1929424) 1929424..1929669 - 246 WP_001164966.1 hypothetical protein -
QQ972_RS09260 (1929669) 1929669..1930490 - 822 WP_097752264.1 DUF932 domain-containing protein -
QQ972_RS09265 (1930590) 1930590..1930823 - 234 WP_001213776.1 DUF905 family protein -
QQ972_RS09270 (1930941) 1930941..1931393 - 453 WP_000682723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-115)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14595.66 Da        Isoelectric Point: 8.2918

>T283722 WP_042004473.1 NZ_CP127255:c1926948-1926562 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 387 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT283722 WP_001285482.1 NZ_CP127255:c1927369-1926995 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References