Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4543773..4544427 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag QQ971_RS22210 Protein ID WP_286004742.1
Coordinates 4543773..4544180 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQ971_RS22215 Protein ID WP_000354046.1
Coordinates 4544161..4544427 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS22190 (4539730) 4539730..4541463 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
QQ971_RS22195 (4541469) 4541469..4542179 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQ971_RS22200 (4542204) 4542204..4543100 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QQ971_RS22205 (4543212) 4543212..4543733 + 522 WP_001055874.1 flavodoxin FldB -
QQ971_RS22210 (4543773) 4543773..4544180 - 408 WP_286004742.1 protein YgfX Toxin
QQ971_RS22215 (4544161) 4544161..4544427 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQ971_RS22220 (4544670) 4544670..4545650 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QQ971_RS22225 (4545846) 4545846..4546505 - 660 WP_000250274.1 hemolysin III family protein -
QQ971_RS22230 (4546669) 4546669..4546980 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
QQ971_RS22235 (4547025) 4547025..4548458 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
QQ971_RS22240 (4548515) 4548515..4549258 - 744 WP_000951948.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16004.99 Da        Isoelectric Point: 10.9373

>T283708 WP_286004742.1 NZ_CP127252:c4544180-4543773 [Escherichia coli]
VVLWQSDLRVSWLAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT283708 WP_000354046.1 NZ_CP127252:c4544427-4544161 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References