Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 101969..102705 Replicon plasmid pOXA10_130119
Accession NZ_CP127231
Organism Klebsiella pneumoniae strain 130119

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag QRA14_RS28245 Protein ID WP_004187044.1
Coordinates 102223..102705 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag QRA14_RS28240 Protein ID WP_003026799.1
Coordinates 101969..102235 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA14_RS28225 (QRA14_28230) 97441..98835 + 1395 WP_032439652.1 cytosine permease -
QRA14_RS28230 (QRA14_28235) 98847..100055 + 1209 WP_032448288.1 imidazolonepropionase -
QRA14_RS28235 (QRA14_28240) 100048..100857 + 810 WP_023329017.1 N-formylglutamate deformylase -
QRA14_RS28240 (QRA14_28245) 101969..102235 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
QRA14_RS28245 (QRA14_28250) 102223..102705 + 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
QRA14_RS28250 (QRA14_28255) 102916..104262 + 1347 WP_077251107.1 ISNCY family transposase -
QRA14_RS28255 (QRA14_28260) 104422..105126 + 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
QRA14_RS28260 (QRA14_28265) 105403..106749 + 1347 WP_077254728.1 ISNCY family transposase -
QRA14_RS28265 (QRA14_28270) 106798..107196 + 399 WP_032422684.1 helix-turn-helix domain-containing protein -
QRA14_RS28270 (QRA14_28275) 107344..107454 - 111 Protein_107 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / dfrA14 / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / blaLAP-2 / qnrS1 iutA / iucD / iucC / iucB / iucA 1..258228 258228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T283652 WP_004187044.1 NZ_CP127231:102223-102705 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT283652 WP_003026799.1 NZ_CP127231:101969-102235 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References