Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 286559..287152 Replicon chromosome
Accession NZ_CP127099
Organism Trueperella bernardiae strain UMB8254

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag QPC17_RS01325 Protein ID WP_285347385.1
Coordinates 286559..286840 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QPC17_RS01330 Protein ID WP_101923791.1
Coordinates 286853..287152 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPC17_RS01310 (QPC17_01310) 283173..283709 + 537 WP_148132171.1 hypothetical protein -
QPC17_RS01315 (QPC17_01315) 284023..285915 - 1893 WP_285347384.1 cation-translocating P-type ATPase -
QPC17_RS01320 (QPC17_01320) 285912..286271 - 360 WP_034662574.1 metalloregulator ArsR/SmtB family transcription factor -
QPC17_RS01325 (QPC17_01325) 286559..286840 + 282 WP_285347385.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QPC17_RS01330 (QPC17_01330) 286853..287152 + 300 WP_101923791.1 HigA family addiction module antitoxin Antitoxin
QPC17_RS01335 (QPC17_01335) 287328..287525 - 198 WP_285347386.1 hypothetical protein -
QPC17_RS01340 (QPC17_01340) 287739..288206 + 468 WP_062613708.1 GNAT family N-acetyltransferase -
QPC17_RS01345 (QPC17_01345) 288593..289051 + 459 WP_285347387.1 hypothetical protein -
QPC17_RS01350 (QPC17_01350) 289136..289729 + 594 WP_070445877.1 nitroreductase family protein -
QPC17_RS01355 (QPC17_01355) 289726..290523 + 798 WP_062613686.1 ATP-binding cassette domain-containing protein -
QPC17_RS01360 (QPC17_01360) 290520..291185 + 666 WP_062613685.1 ABC transporter permease subunit -
QPC17_RS01365 (QPC17_01365) 291169..291831 + 663 WP_068538785.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10913.61 Da        Isoelectric Point: 8.0114

>T283559 WP_285347385.1 NZ_CP127099:286559-286840 [Trueperella bernardiae]
VIISFADRDTEALYLRQPVRWLDFRLNRQALQKLRLLDSVVDLNELKIPPGNRLEALKGDRAGQFSIRINNQWQICFVWT
FMGPSELAIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11090.88 Da        Isoelectric Point: 6.4680

>AT283559 WP_101923791.1 NZ_CP127099:286853-287152 [Trueperella bernardiae]
MGKKISPISPGEVLLEEFIGPMGITQNKLAVEIGVPPRRINEIVHGKRRITADTALRLGRYFGMSAQFWINLQSHYDLEI
EMDALADELDKITPITRGT

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References