Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5226056..5226681 Replicon chromosome
Accession NZ_CP126987
Organism Klebsiella pneumoniae subsp. pneumoniae strain T3

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QP573_RS25260 Protein ID WP_002882817.1
Coordinates 5226056..5226439 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QP573_RS25265 Protein ID WP_004150355.1
Coordinates 5226439..5226681 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP573_RS25245 (5223422) 5223422..5224324 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QP573_RS25250 (5224321) 5224321..5224956 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QP573_RS25255 (5224953) 5224953..5225882 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QP573_RS25260 (5226056) 5226056..5226439 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QP573_RS25265 (5226439) 5226439..5226681 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QP573_RS25270 (5226886) 5226886..5227803 + 918 WP_021466676.1 alpha/beta hydrolase -
QP573_RS25275 (5227817) 5227817..5228758 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QP573_RS25280 (5228803) 5228803..5229240 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QP573_RS25285 (5229237) 5229237..5230097 - 861 WP_004146232.1 virulence factor BrkB family protein -
QP573_RS25290 (5230091) 5230091..5230690 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T283464 WP_002882817.1 NZ_CP126987:c5226439-5226056 [Klebsiella pneumoniae subsp. pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT283464 WP_004150355.1 NZ_CP126987:c5226681-5226439 [Klebsiella pneumoniae subsp. pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References