Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4742017..4742533 Replicon chromosome
Accession NZ_CP126987
Organism Klebsiella pneumoniae subsp. pneumoniae strain T3

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag QP573_RS22940 Protein ID WP_009486548.1
Coordinates 4742017..4742301 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QP573_RS22945 Protein ID WP_002886901.1
Coordinates 4742291..4742533 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP573_RS22915 (4737434) 4737434..4737697 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
QP573_RS22920 (4737827) 4737827..4738000 + 174 WP_032433782.1 hypothetical protein -
QP573_RS22925 (4738003) 4738003..4738746 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QP573_RS22930 (4739103) 4739103..4741241 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QP573_RS22935 (4741549) 4741549..4742013 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QP573_RS22940 (4742017) 4742017..4742301 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP573_RS22945 (4742291) 4742291..4742533 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QP573_RS22950 (4742611) 4742611..4744521 - 1911 WP_009486549.1 PRD domain-containing protein -
QP573_RS22955 (4744544) 4744544..4745698 - 1155 WP_002886900.1 lactonase family protein -
QP573_RS22960 (4745765) 4745765..4746505 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T283462 WP_009486548.1 NZ_CP126987:c4742301-4742017 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT283462 WP_002886901.1 NZ_CP126987:c4742533-4742291 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References