Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 78260..78807 Replicon plasmid pEND_Eco 18005
Accession NZ_CP126947
Organism Escherichia coli O78:H51 strain APEC E18005

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QQA24_RS25260 Protein ID WP_097309154.1
Coordinates 78260..78538 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QQA24_RS25265 Protein ID WP_000079941.1
Coordinates 78538..78807 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA24_RS25230 (74524) 74524..74658 - 135 WP_249531455.1 hypothetical protein -
QQA24_RS25235 (74618) 74618..75559 - 942 WP_001312841.1 3-deoxy-7-phosphoheptulonate synthase -
QQA24_RS25240 (75740) 75740..76040 + 301 Protein_68 hypothetical protein -
QQA24_RS25245 (76118) 76118..76465 - 348 WP_000142437.1 DUF6404 family protein -
QQA24_RS25250 (76767) 76767..77249 - 483 WP_001311056.1 hypothetical protein -
QQA24_RS25255 (77366) 77366..78214 - 849 WP_001058005.1 3'-5' exonuclease -
QQA24_RS25260 (78260) 78260..78538 - 279 WP_097309154.1 type II toxin-antitoxin system toxin YacB Toxin
QQA24_RS25265 (78538) 78538..78807 - 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QQA24_RS25270 (79329) 79329..80557 + 1229 WP_112030635.1 IS3-like element IS2 family transposase -
QQA24_RS25275 (80754) 80754..82028 + 1275 WP_000489607.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / blaCTX-M-1 iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat 1..204838 204838


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10799.42 Da        Isoelectric Point: 8.4615

>T283294 WP_097309154.1 NZ_CP126947:c78538-78260 [Escherichia coli O78:H51]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTVQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT283294 WP_000079941.1 NZ_CP126947:c78807-78538 [Escherichia coli O78:H51]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References